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More than one-third of people living with HIV/AIDS live in the Sub-Sharan Africa region. The study focused on Cameroon, Ethiopia, Ghana, and Zambia to give a general overview of the situation in the region. 2019 data by UNAIDS were assessed and compared with the 2018 data. The results revealed a disproportionate burden of the disease among women aged 15 years and above, as compared to men of the same ages and children below 15 years. Also, it was revealed that ARV services among pregnant women are effective in reducing the number of new infections among newborns. It is this important that in the fight against the epidemic in the region, governments and their development partners should give much attention to women.